Combine ground turkey, panko, egg, red onion, parsley, garlic powder, onion powder, smoked paprika, salt, and black pepper in a large bowl. Mix gently with your hands for about one minute—I use a light touch and stop as soon as everything is combined, because overworking the meat makes the burgers dense and tough rather than light.
Divide the mixture into four equal portions and shape each into a patty about three-quarters inch thick. Make a small indent in the center of each patty with your thumb—this prevents them from puffing up and keeps the cooking even across the burger.
Heat a grill or skillet to medium-high heat and lightly oil the grates. This step matters because ground turkey sticks more easily than beef, so the oil acts as insurance against frustration halfway through cooking.
Place the patties on the grill and resist the urge to move them for 5-6 minutes. I confess I used to flip constantly, thinking that helped, but actually it breaks the developing crust and releases the juices—the burger needs that undisturbed time to develop structure.
Flip each patty once and cook for another 5-6 minutes until the internal temperature reaches 165°F when tested with an instant-read thermometer. The why here is food safety with ground poultry, but also because undercooked turkey tastes off and overcooked turkey turns to rubber—that thermometer is your actual best friend.
Top each burger with a slice of cheddar cheese during the last minute of cooking, then transfer to a clean plate to rest for two minutes. The rest time lets the residual heat finish melting the cheese while the burger settles, so each bite stays cohesive.
Toast the burger buns lightly on the grill or in a skillet for one minute per side. Toasted buns stand up to the moisture from the burger and give the entire thing a more intentional, elegant feel.